Human CD35 (CR1) activation kit by CRISPRa
CAT#: GA100965
CR1 CRISPRa kit - CRISPR gene activation of human complement C3b/C4b receptor 1 (Knops blood group)
CNY 12,255.00
CNY 800.00
CNY 1,999.00
CNY 2,700.00
CNY 21,536.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | CR1 |
Locus ID | 1378 |
Kit Components | GA100965G1, CD35 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100965G2, CD35 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100965G3, CD35 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_000573, NM_000651 |
Synonyms | C3BR; C4BR; CD35; KN |
Summary | This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020] |
Documents
Resources
基因表达相关资源 |
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KN216533 | CR1 - human gene knockout kit via CRISPR, HDR mediated |
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KN216533RB | CR1 - human gene knockout kit via CRISPR, HDR mediated |
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