Human Aromatase (CYP19A1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CYP19A1
Locus ID	1588
Kit Components	GA101117G1, Aromatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101117G2, Aromatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101117G3, Aromatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000103, NM_031226, NM_001347248, NM_001347249, NM_001347250, NM_001347251, NM_001347252, NM_001347253, NM_001347254, NM_001347255, NM_001347256
Synonyms	ARO; ARO1; CPV1; CYAR; CYP19; CYPXIX; P-450AROM
Summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

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