Human DCC activation kit by CRISPRa

CAT#: GA101148

DCC CRISPRa kit - CRISPR gene activation of human DCC netrin 1 receptor



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
DCC mouse monoclonal antibody, clone OTI4A1 (formerly 4A1)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


DCC (Myc-DDK-tagged)-Human deleted in colorectal carcinoma (DCC)
    • 10 ug

CNY 9,904.00


DCC mouse monoclonal antibody, clone OTI5D10 (formerly 5D10)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol DCC
Locus ID 1630
Kit Components

GA101148G1, DCC gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101148G2, DCC gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101148G3, DCC gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_005215
Synonyms CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1
Summary This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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