Human Dopamine Receptor D3 (DRD3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	DRD3
Locus ID	1814
Kit Components	GA101267G1, Dopamine Receptor D3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101267G2, Dopamine Receptor D3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101267G3, Dopamine Receptor D3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000796, NM_001282563, NM_001290809, NM_033658, NM_033659, NM_033660, NM_033663
Synonyms	D3DR; ETM1; FET1
Summary	This gene encodes the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

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