Human Neuronal membrane glycoprotein M6 a (GPM6A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	GPM6A
Locus ID	2823
Kit Components	GA101888G1, Neuronal membrane glycoprotein M6 a gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA101888G2, Neuronal membrane glycoprotein M6 a gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA101888G3, Neuronal membrane glycoprotein M6 a gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001261447, NM_001261448, NM_005277, NM_201591, NM_201592, NR_048571
Synonyms	GPM6; M6A
Summary	Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.[UniProtKB/Swiss-Prot Function]

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