Human Glucocorticoid Receptor (NR3C1) activation kit by CRISPRa

CAT#: GA101964

NR3C1 CRISPRa kit - CRISPR gene activation of human nuclear receptor subfamily 3 group C member 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
NR3C1 mouse monoclonal antibody, clone OTI1B11 (formerly 1B11)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


NR3C1 (Myc-DDK-tagged)-Human nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1), transcript variant 2
    • 10 ug

CNY 8,536.00


NR3C1 mouse monoclonal antibody, clone OTI6B5 (formerly 6B5)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol NR3C1
Locus ID 2908
Kit Components

GA101964G1, Glucocorticoid Receptor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101964G2, Glucocorticoid Receptor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101964G3, Glucocorticoid Receptor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000176, NM_001018074, NM_001018075, NM_001018076, NM_001018077, NM_001020825, NM_001024094, NM_001204258, NM_001204259, NM_001204260, NM_001204261, NM_001204262, NM_001204263, NM_001204264, NM_001204265, NM_001364182, NM_001364184, NR_157096, NM_001364180, NM_001364181, NM_001364183, NM_001364185
Synonyms GCCR; GCR; GCRST; GR; GRL
Summary This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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