Human HLAF (HLA-F) activation kit by CRISPRa
CAT#: GA102139
HLA-F CRISPRa kit - CRISPR gene activation of human major histocompatibility complex, class I, F
CNY 12,255.00
货期*
4周
规格
经常一起买 (2)
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | HLA-F |
Locus ID | 3134 |
Kit Components | GA102139G1, HLAF gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102139G2, HLAF gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102139G3, HLAF gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001098478, NM_001098479, NM_018950 |
Synonyms | CDA12; HLA-5.4; HLA-CDA12; HLAF |
Summary | This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008] |
Documents
Resources
基因表达相关资源 |
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