Human Factor I (CFI) activation kit by CRISPRa
CAT#: GA102318
CFI CRISPRa kit - CRISPR gene activation of human complement factor I
CNY 12,255.00
CNY 1,999.00
CNY 2,700.00
CNY 800.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | CFI |
Locus ID | 3426 |
Kit Components | GA102318G1, Factor I gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102318G2, Factor I gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102318G3, Factor I gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_000204, NM_001318057, NM_001331035, N63668 |
Synonyms | AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF |
Summary | This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uremic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immune deposits and age-related macular degeneration are other conditions associated with mutations of this gene. [provided by RefSeq, Dec 2015] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
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KN416645 | CFI - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |