Human IFNAR2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	IFNAR2
Locus ID	3455
Kit Components	GA102340G1, IFNAR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102340G2, IFNAR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102340G3, IFNAR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000874, NM_001289125, NM_001289126, NM_001289128, NM_207584, NM_207585
Synonyms	IFN-alpha-REC; IFN-R; IFNABR; IFNARB; IMD45
Summary	The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]

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