Human Kininogen 1 (KNG1) activation kit by CRISPRa

CAT#: GA102594

KNG1 CRISPRa kit - CRISPR gene activation of human kininogen 1



  See Other Versions

CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
Rabbit Polyclonal antibody to Kininogen 1 (kininogen 1)
    • 100 ul

CNY 6,281.00


KNG1 (Myc-DDK-tagged)-Human kininogen 1 (KNG1), transcript variant 2
    • 10 ug

CNY 3,656.00
CNY 3,990.00


Kininogen 1 (KNG1) Rabbit polyclonal Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol KNG1
Locus ID 3827
Kit Components

GA102594G1, Kininogen 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102594G2, Kininogen 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102594G3, Kininogen 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000893, NM_001102416, NM_001166451
Synonyms BDK; BK; KNG
Summary This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reduces or depletes angiotensin converting enzyme 2 (ACE2), which results in an increase in levels of des-Arg(9)-bradykinin, a bioactive metabolite of bradykinin that is associated with lung injury and inflammation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2020]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Other Versions

Customer Reviews 
Loading...