Human CD56 (NCAM1) activation kit by CRISPRa

CAT#: GA103115

NCAM1 CRISPRa kit - CRISPR gene activation of human neural cell adhesion molecule 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
NCAM1 (CD56) mouse monoclonal antibody, clone OTI1G4 (formerly 1G4)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


NCAM1 (Myc-DDK-tagged)-Human neural cell adhesion molecule 1 (NCAM1), transcript variant 2
    • 10 ug

CNY 9,424.00


NCAM1/CD56 mouse monoclonal antibody, clone OTI2B9 (formerly 2B9)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol NCAM1
Locus ID 4684
Kit Components

GA103115G1, CD56 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA103115G2, CD56 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA103115G3, CD56 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_000615, NM_001076682, NM_001242607, NM_001242608, NM_181351
Synonyms CD56; MSK39; NCAM
Summary This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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