Human Septin 2 (SEPT2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SEPTIN2
Locus ID	4735
Kit Components	GA103160G1, Septin 2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103160G2, Septin 2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103160G3, Septin 2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001008491, NM_001008492, NM_001282972, NM_001282973, NM_004404, NM_006155, NM_001321029, NM_001321030, NM_001321031, NM_001321032, NM_001321033, NM_001321034, NM_001321035, NM_001349287, NM_001349288, NM_001349289, NM_001349290, NM_001349291, NM_001349302, NM_001349304, NM_001349305, NM_001349306, NM_001349307, NM_001349308, NM_001349309, NM_001349310, NM_001349311, NM_001349312, NM_001349313, NM_001349314, NM_001349315
Synonyms	DIFF6; hNedd5; NEDD-5; NEDD5; Pnutl3
Summary	Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.[UniProtKB/Swiss-Prot Function]

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