Human PFKFB4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PFKFB4
Locus ID	5210
Kit Components	GA103500G1, PFKFB4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103500G2, PFKFB4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103500G3, PFKFB4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001317134, NM_001317135, NM_001317136, NM_001317137, NM_001317138, NM_004567
Synonyms	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4; bifunctional enzyme with kinase and biphosphatase activities
Summary	The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

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