Human PLCL1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PLCL1
Locus ID	5334
Kit Components	GA103594G1, PLCL1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA103594G2, PLCL1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA103594G3, PLCL1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001114661, NM_006226
Synonyms	MGC126580; MGC138190; OTTHUMP00000163640; phospholipase C, epsilon; phospholipase C-like 1; PLC-L; PLCE; PLCL; PLDL1
Summary	Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.[UniProtKB/Swiss-Prot Function]

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