Human Retinoic Acid Receptor beta (RARB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RARB
Locus ID	5915
Kit Components	GA104025G1, Retinoic Acid Receptor beta gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104025G2, Retinoic Acid Receptor beta gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104025G3, Retinoic Acid Receptor beta gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000965, NM_001290216, NM_001290217, NM_001290266, NM_001290276, NM_001290277, NM_001290300, NM_016152, NR_110892, NR_110893
Synonyms	HAP; MCOPS12; NR1B2; RARbeta1; RRB2
Summary	This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]

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