Human RFNG activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	RFNG
Locus ID	5986
Kit Components	GA104080G1, RFNG gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104080G2, RFNG gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104080G3, RFNG gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_002917
Synonyms	beta-1,3-N-acetylglucosaminyltransferase radical fringe; radical fringe homolog; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Summary	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis.[UniProtKB/Swiss-Prot Function]

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