Human Bax inhibitor 1 (TMBIM6) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TMBIM6
Locus ID	7009
Kit Components	GA104820G1, Bax inhibitor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104820G2, Bax inhibitor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104820G3, Bax inhibitor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001098576, NM_003217
Synonyms	BAXI1; BI-1; TEGT
Summary	Suppressor of apoptosis (PubMed:21075086). Modulates unfolded protein response signaling (PubMed:21075086). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).[UniProtKB/Swiss-Prot Function]

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