Human Thymidylate Synthase (TYMS) activation kit by CRISPRa
CAT#: GA105028
TYMS CRISPRa kit - CRISPR gene activation of human thymidylate synthetase
CNY 12,255.00
CNY 1,999.00
CNY 2,700.00
CNY 800.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | TYMS |
Locus ID | 7298 |
Kit Components | GA105028G1, Thymidylate Synthase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105028G2, Thymidylate Synthase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105028G3, Thymidylate Synthase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001071, NM_001354867, NM_001354868 |
Synonyms | HST422; TMS; TS |
Summary | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN404814 | TYMS - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |