Human Thymidylate Synthase (TYMS) activation kit by CRISPRa

CAT#: GA105028

TYMS CRISPRa kit - CRISPR gene activation of human thymidylate synthetase



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
TYMS mouse monoclonal antibody, clone OTI10F12 (formerly 10F12)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


TYMS (Myc-DDK-tagged)-Human thymidylate synthetase (TYMS)
    • 10 ug

CNY 3,600.00


TYMS mouse monoclonal antibody, clone OTI1C4 (formerly 1C4)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol TYMS
Locus ID 7298
Kit Components

GA105028G1, Thymidylate Synthase gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105028G2, Thymidylate Synthase gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105028G3, Thymidylate Synthase gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001071, NM_001354867, NM_001354868
Synonyms HST422; TMS; TS
Summary Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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