Human 14-3-3 zeta (YWHAZ) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	YWHAZ
Locus ID	7534
Kit Components	GA105185G1, 14-3-3 zeta gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105185G2, 14-3-3 zeta gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105185G3, 14-3-3 zeta gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001135699, NM_001135700, NM_001135701, NM_001135702, NM_003406, NM_145690
Synonyms	14-3-3-zeta; HEL-S-3; HEL4; KCIP-1; YWHAD
Summary	This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

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