Human splicing factor 1 (SF1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SF1
Locus ID	7536
Kit Components	GA105187G1, splicing factor 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105187G2, splicing factor 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105187G3, splicing factor 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001178030, NM_001178031, NM_004630, NM_201995, NM_201997, NM_201998, NR_033649, NR_033650, NM_001346363, NM_001346364, NM_001346409, NM_001346410
Synonyms	BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162
Summary	This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

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