Human KIAA0427 (CTIF) activation kit by CRISPRa
CAT#: GA106608
CTIF CRISPRa kit - CRISPR gene activation of human cap binding complex dependent translation initiation factor
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | CTIF |
Locus ID | 9811 |
Kit Components | GA106608G1, KIAA0427 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106608G2, KIAA0427 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106608G3, KIAA0427 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001142397, NM_014772 |
Synonyms | Gm672; KIAA0427 |
Summary | CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM, Dec 2009] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN408324 | CTIF - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |