Human MRP5 (ABCC5) activation kit by CRISPRa

CAT#: GA106814

ABCC5 CRISPRa kit - CRISPR gene activation of human ATP binding cassette subfamily C member 5



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
ABCC5 mouse monoclonal antibody, clone OTI2C8 (formerly 2C8)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


ABCC5 (Myc-DDK-tagged)-Human ATP-binding cassette, sub-family C (CFTR/MRP), member 5 (ABCC5), transcript variant 2
    • 10 ug

CNY 3,600.00


ABCC5 mouse monoclonal antibody, clone OTI2C8 (formerly 2C8)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol ABCC5
Locus ID 10057
Kit Components

GA106814G1, MRP5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA106814G2, MRP5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA106814G3, MRP5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001023587, NM_001320032, NM_005688, NR_135125
Synonyms ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
Summary The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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