Human Unrip (STRAP) activation kit by CRISPRa
CAT#: GA107693
STRAP CRISPRa kit - CRISPR gene activation of human serine/threonine kinase receptor associated protein
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | STRAP |
Locus ID | 11171 |
Kit Components | GA107693G1, Unrip gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107693G2, Unrip gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107693G3, Unrip gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_007178 |
Synonyms | MAWD; PT-WD; UNRIP |
Summary | The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN209149 | STRAP - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN209149BN | STRAP - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN209149LP | STRAP - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN209149RB | STRAP - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
|
KN409149 | STRAP - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |