Human RASSF1 activation kit by CRISPRa

CAT#: GA107707

RASSF1 CRISPRa kit - CRISPR gene activation of human Ras association domain family member 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
RASSF1 mouse monoclonal antibody, clone OTI2B11 (formerly 2B11)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


RASSF1 (Myc-DDK-tagged)-Human Ras association (RalGDS/AF-6) domain family member 1 (RASSF1), transcript variant A
    • 10 ug

CNY 5,488.00


RASSF1 mouse monoclonal antibody, clone OTI8A11 (formerly 8A11)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol RASSF1
Locus ID 11186
Kit Components

GA107707G1, RASSF1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107707G2, RASSF1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107707G3, RASSF1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001206957, NM_007182, NM_170712, NM_170713, NM_170714, NM_170715, NM_170716, NM_170717
Synonyms 123F2; NORE2A; RASSF1A; RDA32; REH3P21
Summary This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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