Human CNOT1 activation kit by CRISPRa
CAT#: GA107973
CNOT1 CRISPRa kit - CRISPR gene activation of human CCR4-NOT transcription complex subunit 1
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | CNOT1 |
Locus ID | 23019 |
Kit Components | GA107973G1, CNOT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107973G2, CNOT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107973G3, CNOT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001265612, NM_016284, NM_206999, NR_049763 |
Synonyms | AD-005; CDC39; NOT1; NOT1H |
Summary | Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3' UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
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KN206903 | CNOT1 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
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KN206903BN | CNOT1 - human gene knockout kit via CRISPR, HDR mediated |
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KN206903LP | CNOT1 - human gene knockout kit via CRISPR, HDR mediated |
CNY 12,260.00 |
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KN206903RB | CNOT1 - human gene knockout kit via CRISPR, HDR mediated |
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KN406903 | CNOT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |