Human CYFIP1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CYFIP1
Locus ID	23191
Kit Components	GA108110G1, CYFIP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108110G2, CYFIP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108110G3, CYFIP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001033028, NM_001287810, NM_014608, NM_001324119, NM_001324120, NM_001324122, NM_001324123, NM_001324124, NM_001324125, NM_001324126
Synonyms	P140SRA-1; SHYC; SRA-1; SRA1
Summary	This gene encodes a protein that regulates cytoskeletal dynamics and protein translation. The encoded protein is a component of the WAVE regulatory complex (WRC), which promotes actin polymerization.This protein also interacts with the Fragile X mental retardation protein (FMRP) and translation initiation factor 4E to inhibit protein translation. A large chromosomal deletion including this gene is associated with increased risk of schizophrenia and epilepsy in human patients. Reduced expression of this gene has been observed in various human cancers and the encoded protein may inhibit tumor invasion. [provided by RefSeq, May 2017]

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