Human ARHGEF9 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARHGEF9
Locus ID	23229
Kit Components	GA108143G1, ARHGEF9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108143G2, ARHGEF9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108143G3, ARHGEF9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001173479, NM_001173480, NM_001330495, NM_015185, NM_001353921, NM_001353922, NM_001353923, NM_001353924, NM_001353926, NM_001353927, NM_001353928, NM_001369031, NM_001369036, NM_001369037, NM_001369039, NM_001369041, NM_001369043, NM_001369044, NM_001369045, NM_001369030, NM_001369032, NM_001369033, NM_001369034, NM_001369035, NM_001369038, NM_001369040, NM_001369042
Synonyms	COLLYBISTIN; EIEE8; HPEM-2; PEM-2; PEM2
Summary	The protein encoded by this gene is a Rho-like GTPase that switches between the active (GTP-bound) state and inactive (GDP-bound) state to regulate CDC42 and other genes. This brain-specific protein also acts as an adaptor protein for the recruitment of gephyrin and together these proteins facilitate receceptor recruitement in GABAnergic and glycinergic synapses. Defects in this gene are the cause of startle disease with epilepsy (STHEE), also known as hyperekplexia with epilepsy, as well as several other types of cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2017]

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