Human Nicastrin (NCSTN) activation kit by CRISPRa

CAT#: GA108268

NCSTN CRISPRa kit - CRISPR gene activation of human nicastrin



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (2)
Rabbit Polyclonal Anti-NCSTN Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


NCSTN (Myc-DDK-tagged)-Human nicastrin (NCSTN)
    • 10 ug

CNY 5,192.00
CNY 7,410.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol NCSTN
Locus ID 23385
Kit Components

GA108268G1, Nicastrin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108268G2, Nicastrin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108268G3, Nicastrin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001290184, NM_001290186, NM_015331, NM_001349729
Synonyms ATAG1874
Summary This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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