Human FBXL2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FBXL2
Locus ID	25827
Kit Components	GA108566G1, FBXL2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108566G2, FBXL2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108566G3, FBXL2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001171713, NM_012157, NM_001349316, NM_001349319, NM_001349320, NM_001349321, NM_001349322, NM_001349323, NM_001349324, NM_001349325, NM_001349326, NR_146121, NR_146122, NR_146123, NR_146124, NR_146125, NR_146126, NR_146127, NR_146128, NR_146129, NR_146130, NR_146131, NR_146132, NR_146133, NR_146134, NR_146135
Synonyms	FBL2; FBL3
Summary	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

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