Human SUMF2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SUMF2
Locus ID	25870
Kit Components	GA108595G1, SUMF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108595G2, SUMF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108595G3, SUMF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001042468, NM_001042469, NM_001042470, NM_001130069, NM_001130070, NM_001146333, NM_015411, NM_001366647, NM_001366648, NM_001366649
Synonyms	DKFZp566I1024; DKFZp686I1024; DKFZp686L17160; DKFZp781L1035; MGC99485; pFGE
Summary	The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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