Human C5orf45 (MRNIP) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MRNIP
Locus ID	51149
Kit Components	GA109607G1, C5orf45 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109607G2, C5orf45 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109607G3, C5orf45 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001017987, NM_001018061, NM_001018062, NM_016175
Synonyms	DKFZp686L2452; MGC65027; MGC78537
Summary	Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).[UniProtKB/Swiss-Prot Function]

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