Human SUV39H2 activation kit by CRISPRa

CAT#: GA112577

SUV39H2 CRISPRa kit - CRISPR gene activation of human suppressor of variegation 3-9 homolog 2



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
SUV39H2 rabbit polyclonal antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


SUV39H2 (Myc-DDK-tagged)-Human suppressor of variegation 3-9 homolog 2 (Drosophila) (SUV39H2), transcript variant 3
    • 10 ug

CNY 3,656.00
CNY 3,990.00


SUV39H2 rabbit polyclonal antibody
    • 25 ul

CNY 800.00
CNY 1,280.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol SUV39H2
Locus ID 79723
Kit Components

GA112577G1, SUV39H2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA112577G2, SUV39H2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA112577G3, SUV39H2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001193424, NM_001193425, NM_001193426, NM_001193427, NM_024670, NR_034181
Synonyms KMT1B
Summary Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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