Human EHMT1/GLP (EHMT1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	EHMT1
Locus ID	79813
Kit Components	GA112645G1, EHMT1/GLP gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112645G2, EHMT1/GLP gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112645G3, EHMT1/GLP gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001145527, NM_024757, NM_001354259, NM_001354263, NM_001354611, NM_001354612
Synonyms	bA188C12.1; Eu-HMTase1; EUHMTASE1; FP13812; GLP; GLP1; KMT1D
Summary	The protein encoded by this gene is a histone methyltransferase that methylates the lysine-9 position of histone H3. This action marks the genomic region packaged with these methylated histones for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome, also known as Kleefstra syndrome). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

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