Human ASCC2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ASCC2
Locus ID	84164
Kit Components	GA113401G1, ASCC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113401G2, ASCC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113401G3, ASCC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001242906, NM_032204, NM_001369921, NM_001369922, NM_001369925, NM_001369926, NM_001369927, NM_001369930, NM_001369931, NM_001369936, NM_001369938, NM_001369939, NM_001369942, NM_001369945, NM_001369949, NM_001369920, NM_001369923, NM_001369924, NM_001369928, NM_001369929, NM_001369932, NM_001369933, NM_001369934, NM_001369935, NM_001369937, NM_001369940, NM_001369941, NM_001369943, NM_001369944, NM_001369946, NM_001369947, NM_001369948, NM_001369950
Synonyms	ASC1p100; p100
Summary	Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).[UniProtKB/Swiss-Prot Function]

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