Human ZGPAT activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZGPAT
Locus ID	84619
Kit Components	GA113608G1, ZGPAT gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113608G2, ZGPAT gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113608G3, ZGPAT gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001083113, NM_001195653, NM_001195654, NM_032527, NM_181484, NM_181485
Synonyms	GPATC6; GPATCH6; KIAA1847; ZC3H9; ZC3HDC9; ZIP
Summary	Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.[UniProtKB/Swiss-Prot Function]

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