Human MVB12B activation kit by CRISPRa
CAT#: GA113942
MVB12B CRISPRa kit - CRISPR gene activation of human multivesicular body subunit 12B
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | MVB12B |
Locus ID | 89853 |
Kit Components | GA113942G1, MVB12B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113942G2, MVB12B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113942G3, MVB12B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001011703, NM_033446 |
Synonyms | C9orf28; FAM125B |
Summary | The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN405093 | MVB12B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |