Human ZDHHC19 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ZDHHC19
Locus ID	131540
Kit Components	GA115147G1, ZDHHC19 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115147G2, ZDHHC19 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115147G3, ZDHHC19 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001039617, NM_144637, NR_135617, NR_135618
Synonyms	DHHC19
Summary	Palmitoyltransferase that mediates palmitoylation of STAT3 and RRAS (PubMed:31462771, PubMed:20074548). Palmitoylation of STAT3 induces the homodimerization and transcriptional activation of STAT3, thereby, promoting inflammation and cancer (PubMed:31462771). Palmitoylation of RRAS is linked to cell viability (PubMed:20074548). May be involved in S-stearoylation of STAT3 (Probable).[UniProtKB/Swiss-Prot Function]

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