Human C9orf72 activation kit by CRISPRa

CAT#: GA116437

C9orf72 CRISPRa kit - CRISPR gene activation of human C9orf72-SMCR8 complex subunit



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (2)
C9orf72 Rabbit polyclonal Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00


C9orf72 (Myc-DDK-tagged)-Human chromosome 9 open reading frame 72 (C9orf72), transcript variant 2
    • 10 ug

CNY 5,488.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol C9orf72
Locus ID 203228
Kit Components

GA116437G1, C9orf72 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA116437G2, C9orf72 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA116437G3, C9orf72 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001256054, NM_018325, NM_145005
Synonyms ALSFTD; DENNL72; FTDALS; FTDALS1
Summary The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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