Human UBE2V1 (TMEM189-UBE2V1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PEDS1-UBE2V1
Locus ID	387522
Kit Components	GA117890G1, UBE2V1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA117890G2, UBE2V1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA117890G3, UBE2V1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_003349, NM_199203
Synonyms	CROC-1B; Kua; Kua-UEV; OTTHUMP00000031794; transmembrane protein 189; UBE2V1; ubiquitin-conjugating enzyme E2 variant 1; ubiquitin-conjugating enzyme variant Kua
Summary	The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

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