Mouse Cacna1c activation kit by CRISPRa
CAT#: GA200477
Cacna1c CRISPRa kit - CRISPR gene activation of mouse calcium channel, voltage-dependent, L type, alpha 1C subunit
CNY 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | Cacna1c |
Locus ID | 12288 |
Kit Components | GA200477G1, Cacna1c gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200477G2, Cacna1c gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200477G3, Cacna1c gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
Reference Data | |
RefSeq | NM_001159533, NM_001159534, NM_001159535, NM_001255997, NM_001255998, NM_001255999, NM_001256000, NM_001256001, NM_001256002, NM_001290335, NM_009781 |
Synonyms | Cav1.2; Cchl1a1; D930026N18Rik; MBC; MELC-CC |
Summary | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:14609949, PubMed:18586882, PubMed:21216955, PubMed:25368181, PubMed:28119464). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:21216955). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:14609949, PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN502415 | Cacna1c - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. |
CNY 8,680.00 |
其它Cacna1c产品