Mouse Ctnnd1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ctnnd1
Locus ID	12388
Kit Components	GA200549G1, Ctnnd1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200549G2, Ctnnd1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200549G3, Ctnnd1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001085448, NM_001085449, NM_001085450, NM_001085453, NM_007615, NM_001355064, NM_001355065, NM_001355066, NM_001355067
Synonyms	AA409437; AU019353; Catns; Ctnnd; mKIAA0384; P120
Summary	Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.[UniProtKB/Swiss-Prot Function]

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