Mouse Runx1t1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Runx1t1
Locus ID	12395
Kit Components	GA200555G1, Runx1t1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200555G2, Runx1t1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200555G3, Runx1t1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001111026, NM_001111027, NM_009822
Synonyms	Cbfa2t1h; ETO; MTG8
Summary	Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis (PubMed:23527555).[UniProtKB/Swiss-Prot Function]

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