Mouse Ccr4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ccr4
Locus ID	12773
Kit Components	GA200775G1, Ccr4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA200775G2, Ccr4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA200775G3, Ccr4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_009916
Synonyms	C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r
Summary	High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.[UniProtKB/Swiss-Prot Function]

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