Mouse Hsph1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Hsph1
Locus ID	15505
Kit Components	GA202014G1, Hsph1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202014G2, Hsph1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202014G3, Hsph1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001347534, NM_013559
Synonyms	105kDa; AI790491; hsp-E7I; Hsp105; Hsp110; hsp110/105
Summary	Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236).[UniProtKB/Swiss-Prot Function]

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