Mouse Ifnar2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ifnar2
Locus ID	15976
Kit Components	GA202079G1, Ifnar2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202079G2, Ifnar2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202079G3, Ifnar2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001110498, NM_001347258, NM_010509
Synonyms	AI747302; Ifnar-2
Summary	Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 2 and isoform 3 may be potent inhibitors of type I IFN receptor activity.[UniProtKB/Swiss-Prot Function]

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