Mouse Igfbp3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Igfbp3
Locus ID	16009
Kit Components	GA202094G1, Igfbp3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202094G2, Igfbp3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202094G3, Igfbp3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_008343
Synonyms	AI649005; IGFBP-3; IGgfbp3
Summary	IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.[UniProtKB/Swiss-Prot Function]

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