Mouse Kcnn4 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Kcnn4
Locus ID	16534
Kit Components	GA202283G1, Kcnn4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202283G2, Kcnn4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202283G3, Kcnn4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001163510, NM_008433
Synonyms	IK1; IKCA1; KCa3.1; KCA4; mIKCa1; SK4; SKCas
Summary	Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:9705284). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:20884616). Plays a role in the late stages of EGF-induced macropinocytosis (By similarity).[UniProtKB/Swiss-Prot Function]

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