Mouse Il1rl1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Il1rl1
Locus ID	17082
Kit Components	GA202524G1, Il1rl1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA202524G2, Il1rl1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA202524G3, Il1rl1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001025602, NM_001294171, NM_010743
Synonyms	DER4; Fit-1; Ly84; St2; St2-rs1; ST2L; T1; T1/ST2
Summary	Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP (PubMed:18450470, PubMed:17675517). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function.[UniProtKB/Swiss-Prot Function]

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