Mouse Prom1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Prom1
Locus ID	19126
Kit Components	GA203402G1, Prom1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203402G2, Prom1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203402G3, Prom1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001163577, NM_001163578, NM_001163581, NM_001163582, NM_001163583, NM_001163584, NM_001163585, NM_008935
Synonyms	4932416E19Rik; AC133; CD133; Prom; Prom-1; Proml1
Summary	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.[UniProtKB/Swiss-Prot Function]

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