Mouse Rtn3 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Rtn3
Locus ID	20168
Kit Components	GA203731G1, Rtn3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203731G2, Rtn3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203731G3, Rtn3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001003930, NM_001003933, NM_001003934, NM_001271486, NM_001271487, NM_053076
Synonyms	RTN3-A1
Summary	May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (By similarity). Induces the formation of endoplasmic reticulum tubules (PubMed:24262037).[UniProtKB/Swiss-Prot Function]

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